Research Articles
The Goldilocks Zone of Hormesis: A Researcher's Guide to Precise Dosing in Adaptive Stress Experiments
This article provides a comprehensive framework for researchers and drug development professionals to design robust hormesis experiments by avoiding the critical pitfalls of underdosing and overdosing.
Autophagy as a Central Mediator of Hormesis: Mechanisms, Measurement, and Therapeutic Potential
This article provides a comprehensive analysis of autophagy's pivotal role in mediating hormetic responses—the biphasic dose-response phenomenon where low-level stressors confer adaptive benefits.
A Practical Guide to Assessing Mitochondrial Function for Mitohormesis Research: Techniques, Optimization, and Validation
This article provides a comprehensive guide for researchers investigating the beneficial adaptive response of mitohormesis.
Hormesis and Antioxidant Defense: Mechanisms, Measurement, and Therapeutic Potential for Biomedical Research
This article provides a comprehensive analysis of the upregulation of antioxidant defense systems as a central mechanism in hormetic responses.
Detecting Extracellular Hydrogen Peroxide: A Comprehensive Guide to the Amplex Red Assay Protocol
This article provides a complete guide to the Amplex Red/horseradish peroxidase (HRP) assay for detecting and quantifying extracellular hydrogen peroxide (H₂O₂).
Mastering the Amplex Red Assay: A Complete Guide to Extracellular H₂O₂ Detection for Biomedical Research
This comprehensive guide details the Amplex Red/horseradish peroxidase (HRP) assay for sensitive, specific detection of extracellular hydrogen peroxide (H₂O₂).
Overcoming Kinetic Hurdles: Advanced Strategies for Accurate Redox Signaling Measurement in Biomedical Research
This article provides a comprehensive guide for researchers and drug development professionals on addressing kinetic limitations in redox signaling measurements.
Beyond the Average Dose: Decoding Individual Variability in Hormetic Responses for Precision Therapeutics
This article provides a comprehensive analysis of the significant inter-individual variability observed in hormetic responses—the biphasic dose-response phenomenon where low doses of stressors stimulate beneficial adaptations while high doses cause...
Navigating the Maze: A Comprehensive Guide to Identifying and Mitigating Compartment-Specific Redox Signaling Artifacts in Biomedical Research
This article provides a detailed guide for researchers and drug development professionals on addressing the critical challenge of compartment-specific redox signaling artifacts.
Mapping the Genome's Redox Switchboard: A Guide to ATAC-seq for Chromatin Accessibility in Redox Signaling Research
This article provides a comprehensive guide for researchers on integrating ATAC-seq to study chromatin accessibility changes driven by redox signaling.